崔剑方

教育背景

博士（中国科学院上海有机化学研究所）

学士（中山大学）

研究领域
不对称催化；金属有机化学；合成方法学；荧光探针的合成与应用
电子邮件
cuijf@cuhk.edu.cn
个人简介

崔剑方2006年本科毕业于中山大学化学与化学工程学院，获理学学士学位；2011年在中国科学院上海有机化学研究所获理学博士学位（导师：黄乃正教授）。2012年至2018年在香港理工大学应用生物及化学科技系从事博士后研究（导师：黄文健教授），先后担任Research Associate，Postdoctoral Fellow和Research Fellow 等职位；在此期间亦兼职担任理大科技顾问有限公司（PolyU Technology and Consultancy Company Limited）的科技顾问。2018年至2023年，任南方科技大学化学系研究助理教授（副研究员）。2023年加入香港中文大学（深圳），在理工学院担任研究助理教授，主要研究兴趣为不对称催化、合成方法学和金属有机化学等领域；重点聚焦于手性四苯并环辛四烯化合物的合成及其作为手性配体在不对称催化中的应用，以及手性金(III)配合物和荧光探针的合成与应用。

学术著作

(#co-first author, *corresponding author)

  1. Hao-Ran Ma, Xiao-Shui Peng, Jian-Fang Cui*, Henry N. C. Wong*. Emerging optically active tetraphenylenes: advance and challenge in synthesis and applications in asymmetric catalysis and chiral functional materials. Tetrahedron Lett. 2023, 119, 154429.
  2. Wa-Yi O#, Jian-Fang Cui#*, Qiong Yu, Karen Ka-Yan Kung, Sai-Fung Chung, Yun-Chung Leung*, Man-Kin Wong*. Isoindolium-based Allenes: reactivity studies and applications in fluorescence temperature sensing and cysteine bioconjugation. Angew. Chem. Int. Ed. 2023, 62, e202218038.
  3. Jia Guo, Hao-Ran Ma, Wen-Bin Xiong, Luoyi Fan, You-Yun Zhou*, Henry N. C. Wong*, Jian-Fang Cui*. Iridium-catalyzed enantioselective alkynylation and kinetic resolution of alkyl allylic alcohols. Chem. Sci. 2022, 13, 13914-13921.
  4. Ming-Shang Liu, Hai-Wu Du, Jian-Fang Cui, Wei Shu*. Intermolecular metal-free cyclopropanation and aziridination of alkenes with XH2 (X = N, C) by thianthrenation. Angew. Chem. Int. Ed. 2022, 61, e2022099.
  5. Jia Guo, Wen-Bin Xiong, Hao-Ran Ma, Luoyi Fan, You-Yun Zhou, Henry N. C. Wong, Jian-Fang Cui*. Optical resolution of 1,16-dihydroxytetraphenylene by chiral gold(III) complexation and its applications as chiral ligands in asymmetric catalysis. Chem. Sci. 2022, 13, 4608-4615.
  6. Jian-Fang Cui#, Qiong Yu#, Wa-Yi O#, Li-Wu Huang, Bin Yang, Man-Kin Wong*. Synthesis of 1H-isoindoliums by electrophile-mediated cascade cyclization/iodination of propargylamine-based 1,6-diynes. Org. Biomol. Chem. 2022, 20, 3755-3762.
  7. Hok-Ming Ko, Jie-Ren Deng, Jian-Fang Cui, Karen Ka-Yan Kung*, Yun-Chung Leung*, Man-Kin Wong*. Selective modification of alkyne-linked peptides and proteins by cyclometalated gold(III) (C^N) complex-mediated alkynylation. Bioorg. Med. Chem. 2020, 28, 115375.
  8. Zuo-Cheng Qiu, Yan Zhang, Hui-Hui Xiao, Christina Chui-Wa Poon, Xiao-Li Li, Jian-Fang Cui, Man-Kin Wong, Xin-Sheng Yao, Man-Sau Wong*. 8-Prenylgenistein exerts osteogenic effects via ER α and Wnt-dependent signaling pathway. Exp. Cell Res. 2020, 395, 112186.
  9. Jie-Ren Deng, Sai-Fung Chung, Alan Siu-Lun Leung, Wai-Ming Yip, Bin Yang, Man-Chung Choi, Jian-Fang Cui, Karen Ka-Yan Kung, Zhen Zhang, Kar-Wai Lo, Yun-Chung Leung*, Man-Kin Wong*. Chemoselective and photocleavable cysteine modification of peptides and proteins using isoxazoliniums. Commun. Chem. 2019, 2, DOI: 10.1038/s42004-019-0193-5.
  10. Jia-Jun Jiang#, Jian-Fang Cui#, Bin Yang, Yulu Ning, Nathanael Chun-Him Lai, Man-Kin Wong*. Chiral cyclometalated oxazoline gold(III) complex-catalyzed asymmetric carboalkoxylation of alkynes. Org. Lett. 2019, 21, 6289-6294.
  11. Jian-Fang Cui#, Bin Yang#, Qiong Yu, Nathanael Chun-Him Lai, Han Chen, Man-Kin Wong*. Silver-mediated organic transformations of propargylamines to enones, α-thioketones, and isochromans. ChemistrySelect 2019, 4, 1476-1482.
  12. Jian-Fang Cui, Ri-Shi Tang, Bin Yang, Nathanael Chun-Him Lai, Jie-Ren Deng, Man-Kin Wong*. Metal-Free cyclocarboamination of ortho-formyl phenylacetylenes with secondary amines: access to 1,3-diamino-1H-indenes and 3-amino-1-indanones. Adv. Synth. Catal. 2019, 361, 569-577.
  13. Jian-Fang Cui, Hok-Ming Ko, Ka-Pan Shing, Jie-Ren Deng, Nathanael Chun-Him Lai, Man-Kin Wong*. C,O-Chelated BINOL/gold(III) complexes: synthesis and catalysis with tunable product profiles. Angew. Chem. Int. Ed. 2017, 56, 3074-3079.
  14. Bin Yang, Jian-Fang Cui*, Man-Kin Wong*. Selective C-H bond hydroxylation of cyclohexanes in water by supramolecular control. RSC Adv. 2017, 7, 30886-30893.
  15. Tsz-Wai Hui#, Jian-Fang Cui#, Man-Kin Wong*. Modular synthesis of propargylamine modified cyclodextrins by a gold(III)-catalyzed three-component coupling reaction. RSC Adv. 2017, 7, 14477-14480.
  16. Franco King-Chi Leung, Jian-Fang Cui, Tze-Wai Hui, Karen Ka-Yan Kung, Man-Kin Wong*. Photooxidative amidation of aldehydes with amines catalyzed by rose bengal. Asian. J. Org. Chem. 2015, 4, 533-536.
  17. Jian-Fang Cui, Karen Ka-Yan Kung, Hok-Ming Ko, Tsz-Wai Hui, Man-Kin Wong*. Silver-catalyzed transformation of propargylic amine N-oxides to enones and acyloxy ketones via isoxazolinium intermediates. Adv. Synth. Catal. 2014, 356, 2965-2973.
  18. Karen Ka-Yan Kung, Hok-Ming Ko, Jian-Fang Cui, Hiu-Chi Chong, Yun-Chung Leung, Man-Kin Wong*. Cyclometalated gold(III) complexes for chemoselective cysteine modification via ligand controlled C-S bond-forming reductive elimination. Chem. Commun. 2014, 50, 11899-11902.
  19. Franco King-Chi Leung, Jian-Fang Cui, Tsz-Wai Hui, Zhong-Yuan Zhou, Man-Kin Wong*. Hydrogen bond donor–acceptor–donor organocatalysis for conjugate addition of benzylidene barbiturates via complementary DAD–ADA hydrogen bonding. RSC Adv. 2014, 4, 26748-26756.
  20. Hok-Ming Ko, Karen Ka-Yan Kung, Jian-Fang Cui, Man-Kin Wong*. Bis-cyclometallated gold(III) complexes as efficient catalysts for synthesis of propargylamines and alkylated indoles. Chem. Commun. 2013, 49, 8869-8871.
  21. Jian-Fang Cui, Chao Chen, Xiang Gao, Zong-Wei Cai, Jian-Wei Han, Henry Nai Ching Wong*. 2,3,10,11-Tetrahydroxytetraphenylene and its application in molecular recognition. Helv. Chim. Acta. 2012, 95, 2604–2620.
  22. Jian-Fang Cui, Hui Huang, Henry N. C. Wong*. A concise synthetic approach towards hydroxytetraphenylenes. Synlett 2011, 1018-1022.
  23. Yan Liu, Zhuofeng Ke, Jianfang Cui, Wen-Hua Chen, Lin Ma, Bo Wang*. Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as α-glucosidase inhibitors. Bioorg. Med. Chem. 2008, 16, 7185-7192.